Comparison of Clinical Efficacy of Ceftiofur vs Ceftiofur Plus Banamine

Lockwood PW, Katz TL, Johnson JC: Comparative clinical efficacy of three non-steroidal anti-inflammatory drugs (NSAID's) flunixin meglumine, carprofen, and ketoprofen when used as an adjunct to the antibacterial treatment of bovine respiratory disease. Proceedings 15^th Veterinary Respiratory Symposium, The Comparative Respiratory Society P/6.3, 1997.

Protocol

400-lb mixed breed beef calves with naturally occurring pneumonia 7 days after transport.

Calves with pyrexia (>40.0°C), clinical illness index and/or depression score of 2 or 3, and a dyspnea score of 1 or more.

Cases ranked by temperature and randomly assigned to one of two groups:

Treated with ceftiofur only at 1.1 mg/kg once daily for 3 days (n=17).

Treated with ceftiofur plus Banamine at 2.2 mg/kg once daily for 3 days (n=17)

Results - Antibiotic Plus Banamine

Statistically significant (p=<.05) decrease in temperature at 2, 4, 6, 12, and 24 hours.

Statistically significant (p=<.05) decrease in temperature on Day 1 (1.2°F vs 0.5°F).

Statistically significant (p=.0033) reduction in lung consolidation (1.7% vs 15.3%).