The first study was a 12-month reproductive study in which six intravenous injections of flunixin at 3X (6.6 mg/kg) the recommended high end of the dose range were administered to pregnant cattle during selected time points of each trimester of pregnancy. Healthy cows were observed for estrus and bred artificially with frozen semen from the same bull. Twenty four pregnant females were divided into groups of 12 each, treated and control. The treated group received two IV injections of flunixin at approximately 90 days, 150 days and 265 days of pregnancy. Offspring were weighed at birth and 30 days of age and observed for any abnormalities.
In conclusion, no adverse effects in the cows or calves were attributed to intravenous injections of flunixin meglumine given at 3X the recommended dose two times during each trimester of pregnancy.
A second study involved treatment of animals prior to breeding, 12/13 days, 36/37 days, 112/113 days, 210/211 days and 265/266 days post breeding. At each time point, animals received 6.6 mg/kg IV on two consecutive days. All animals were allowed to calve naturally and calves were observed at birth and at 30 days.
In conclusion, no adverse effects in the cows or calves were attributed to flunixin intravenous injections administered to the cows at 6.6 mg/kg for 2 days at 6 time points during the reproductive cycle.